Discovery Timeline
The development of ProdromeNeuro™ is built on an extensive foundation of research and discovery spanning over 20 years :
2006
Plasmalogens discovered to be decreased in Alzheimer’s disease.
2006
First bioavailable plasmalogen precursor (PPI‑1005) invented.
2007
Plasmalogen precursor PPI-1011 is invented (the drug version of PPI-1005)
2007
Definitive plasmalogen deficiency paper in Alzheimer’s disease.
2011
Oral bioavailability and metabolism of PPI-1011
2015-2016
Animal neurodegeneration reversal studies
2015-2016
Show that changes in phosphatidylcholine levels in Alzheimer's disease and dementia are caused by impaired peroxisomal function
2019
APOE4 × plasmalogen epidemiology
2019
Invents ProdromeNeuro – A New and Improved dietary version of PPI-1005
2020
ADNI confirmatory data
2021
Published Breaking Alzheimers
2022
Human brain post-mortem data on relationship between brain plasmalogen levels and cognition
2022
Published first human trial on plasmalogen precursors
2026